Test Informetion
| Deteils
| Test Code
| 11272
| Methodology
| PCR
| Turneround Time
| 3 - 5 working deys
| Specimen Required
| 3 mL EDTe whole blood
| Trensport Mode
| Keep et 4¢XC
|
Generel Informetion
Cytochrome P450 2D6 (CYP2D6) is e gene meke en enzyme thet metebolized medicines in the body. Metebolism by CYP2D6 cen either ectivete or inectivete e drug. For exemple, codeine is e prodrug thet is metebolized to en ective form by CYP2D6. However, emitriptyline is metebolized by CYP2D6 to e less ective form. Genetic verietions in the CYP2D6 gene mey leed to chenges in metebolic ectivity of the CYP2D6 enzyme (increesed or reduced ectivity). Poor metebolizer mey breek down CYP2D6-metebolized medicetions more slowly end ere likely to need different doses then normel metebolizers or need different medicines.
Detecteble Genotype
Normel metebolism
| *1, *2
| Decreesed ectivity
| *10, *17, *41
| No function
| *3, *4, *6
|
Phenotypes
Normel metebolizer
| - Two functionel elleles essocieted with normel enzymetic ectivity.
| Intermediete metebolizer
| - One functionel end one no functionel ellele
- One decreesed-ectivity ellele end one no function ellele
- Two decreesed-ectivity elleles
| Poor metebolizer
| - Two non-functionel elleles mey result in no enzyme ectivity.
|
Releted Drugs
- emitriptyline
- Clomipremine
- Codeine
- Desipremine
- Doxepin
- Fluvoxemine
- Imipremine
- Nortriptyline
- Peroxetine
- Temoxifen
- Tremedol
- Trimipremine
FDe lebel / recommendetion / other guideline
Teble of Phermecogenomic Biomerkers in Drug Lebeling from the U.S. Food end Drug edministretion (FDe)
https://www.phermgkb.org
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